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. 2005 Nov;49(11):4757-9.
doi: 10.1128/AAC.49.11.4757-4759.2005.

Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata

Marçal Mariné  1 , Carolina Serena, Belkys Fernández-Torres, F Javier Pastor, Josep Guarro
Affiliations

Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata

Marçal Mariné et al. Antimicrob Agents Chemother. 2005 Nov.

Abstract

We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

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Figures

FIG. 1.
FIG. 1.
Survival of mice after inoculation with C. glabrata. Mice were inoculated intravenously with either 2 × 107 (FMR 8489, □), 2 × 108 (FMR 8489, ▪; FMR 8497, ▾; FMR 8766, ⋄), or 6 × 108 (FMR 8766, ⧫) CFU/animal.
FIG. 2.
FIG. 2.
Cumulative mortality of mice infected with C. glabrata FMR 8497 (A), FMR 8489 (B), and FMR 8766 (C). a, P value of <0.05 versus control.
FIG. 3.
FIG. 3.
Effects of the antifungal treatments on colony counts of the C. glabrata strains FMR 8497 (A) and FMR 8489 (B) in spleens and kidneys of mice. a, P value of <0.05 versus control. Horizontal lines indicate mean values.
See this image and copyright information in PMC

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