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Comparative Study
. 2005 Nov;49(11):4787-8.
doi: 10.1128/AAC.49.11.4787-4788.2005.

Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora

Itzhak Brook  1 , Perry A Foote
Affiliations
Comparative Study

Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora

Itzhak Brook et al. Antimicrob Agents Chemother. 2005 Nov.

Abstract

Core tonsillar cultures were obtained from 40 children with recurrent tonsillitis treated with either penicillin or cefdinir. Group A beta-hemolytic streptococci were isolated from 11 penicillin- and 3 cefdinir-treated (P < 0.001) patients. beta-Lactamase producers were recovered from 17 penicillin- and 3 cefdinir-treated (P < 0.01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients.

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References

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    1. Brook, I., and P. Yocum. 1984. Quantitative measurement of beta-lactamase in tonsils of children with recurrent tonsillitis. Acta Oto-Laryngol. 98:556-559. - PubMed
    1. Brook, I., and J. D. Gilmore. 1993. Evaluation of bacterial interference and beta-lactamase production in management of experimental infection with group A beta-hemolytic streptococci. Antimicrob. Agents Chemother. 37:1452-1455. - PMC - PubMed
    1. Brook, I., and A. E. Gober. 1995. Role of bacterial interference and beta-lactamase-producing bacteria in the failure of penicillin to eradicate group A streptococcal pharyngotonsillitis. Arch. Otolaryngol. Head Neck Surg. 121:1405-1409. - PubMed
    1. Casey, J. R., and M. E. Pichichero. 2004. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics 113:866-882. - PubMed

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