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Review
. 2005 Nov;8(11):1437-9.
doi: 10.1038/nn1105-1437.

The role of neuroadaptations in relapse to drug seeking

Yavin Shaham  1 , Bruce T Hope
Affiliations
Review

The role of neuroadaptations in relapse to drug seeking

Yavin Shaham et al. Nat Neurosci. 2005 Nov.

Abstract

One of the most difficult problems in treating addiction is not withdrawing addicts from drugs, but preventing relapse. Persistent neuroadaptations are thought to underlie aspects of addiction, including relapse. This commentary assesses the degree to which these neuroadaptations, primarily identified in preclinical studies on cocaine, induce relapse.

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