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Comparative Study
. 2006 Apr 28;82(2):177-81.
doi: 10.1016/j.drugalcdep.2005.09.011. Epub 2005 Oct 25.

Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang  1 , In Kyoon Lyoo, Seog Ju Kim, Young Hoon Sung, Soojeong Bae, Sung-Nam Cho, Ho Young Lee, Dong Soo Lee, Perry F Renshaw
Affiliations
Comparative Study

Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang et al. Drug Alcohol Depend. .

Abstract

Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users.

Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ((99m)Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (>or=6 months) abstinence.

Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users.

Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

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