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. 2005 Dec;77(4):519-21.
doi: 10.1002/jmv.20487.

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Elisabeth Nicand  1 , Gregory L Armstrong, Vincent Enouf, Jean Paul Guthmann, Jean-Philippe Guerin, Mélanie Caron, Jacques Yves Nizou, Roberta Andraghetti
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Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Elisabeth Nicand et al. J Med Virol. 2005 Dec.

Abstract

The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted in Chad. A comparison of the sequences in the ORF2 region of 23 Sudanese isolates and five HEV samples from the two Chadian camps displayed a high similarity (>99.7%) to strains belonging to Genotype 1. But four isolates collected in one of the Chadian camps were close to Genotype 2. Circulation of divergent strains argues for possible multiple sources of infection.

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