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. 2006 Jun;134(3):472-7.
doi: 10.1017/S0950268805005340. Epub 2005 Oct 28.

Survival of a national cohort of hepatitis C virus infected patients, 16 years after exposure

H E Harris  1 , M E Ramsay, N J Andrews; HCV National Register Steering Group
Affiliations

Survival of a national cohort of hepatitis C virus infected patients, 16 years after exposure

H E Harris et al. Epidemiol Infect. 2006 Jun.

Abstract

The aim of this study was to describe the natural history of HCV after 16 years of infection, in a cohort of individuals who acquired their infections on a known date in the United Kingdom. A total of 924 HCV-infected transfusion recipients (cases) and 475 anti-HCV negative transfusion recipients (controls) were eligible for inclusion in the study. Survival was compared between cases and controls to see if there was any excess mortality attributable to HCV. The results show that all-cause mortality was not significantly different between cases and controls (hazard ratio 1.17, 95% CI 0.92-1.49, P=0.21). However, the risk of death directly from liver disease was higher in cases than controls (hazard ratio 2.71, 95% CI 1.09-6.75, P=0.03). Nearly 30% of those HCV-infected cases who died directly from liver disease were known to have consumed excess alcohol.

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Figures

Fig. 1
Fig. 1
Mortality amongst 924 eligible cases (▪) and 475 eligible controls (□).
Fig. 2
Fig. 2
Kaplan–Meier survival curve for HCV cases and controls.
See this image and copyright information in PMC

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