Review
doi: 10.1016/j.devcel.2005.10.005.
Pak GITs to Aurora-A
Affiliations
- PMID: 16256730
- DOI: 10.1016/j.devcel.2005.10.005
Item in Clipboard
Review
Pak GITs to Aurora-A
Dev Cell.
2005 Nov.
Free article
Abstract
The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.
Similar articles
-
alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase.Oncogene. 1999 Oct 7;18(41):5680-90. doi: 10.1038/sj.onc.1202936. Oncogene. 1999. PMID: 10523848
-
The genetics of Pak.J Cell Sci. 2004 Sep 1;117(Pt 19):4343-54. doi: 10.1242/jcs.01392. J Cell Sci. 2004. PMID: 15331659 Review.
-
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).Biochemistry. 2005 Aug 23;44(33):10977-83. doi: 10.1021/bi050374a. Biochemistry. 2005. PMID: 16101281
-
AlphaPIX and betaPIX and their role in focal adhesion formation.Eur J Cell Biol. 2006 Apr;85(3-4):265-74. doi: 10.1016/j.ejcb.2005.10.007. Epub 2005 Dec 5. Eur J Cell Biol. 2006. PMID: 16337026 Review.
-
Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.Cancer J. 2001 May-Jun;7(3):191-202. Cancer J. 2001. PMID: 11419027
Cited by
-
Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases.Cancer Metastasis Rev. 2020 Sep;39(3):583-601. doi: 10.1007/s10555-020-09922-6. Epub 2020 Aug 21. Cancer Metastasis Rev. 2020. PMID: 32820388 Review.
-
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.Front Oncol. 2015 Dec 23;5:283. doi: 10.3389/fonc.2015.00283. eCollection 2015. Front Oncol. 2015. PMID: 26779436 Free PMC article. Review.
-
PAK1-Dependent Regulation of Microtubule Organization and Spindle Migration Is Essential for the Metaphase I-Metaphase II Transition in Porcine Oocytes.Biomolecules. 2024 Feb 17;14(2):237. doi: 10.3390/biom14020237. Biomolecules. 2024. PMID: 38397472 Free PMC article.
-
PAK1 Is Involved in the Spindle Assembly during the First Meiotic Division in Porcine Oocytes.Int J Mol Sci. 2023 Jan 6;24(2):1123. doi: 10.3390/ijms24021123. Int J Mol Sci. 2023. PMID: 36674642 Free PMC article.
-
Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry.Cell Cycle. 2014;13(14):2211-21. doi: 10.4161/cc.29279. Epub 2014 May 19. Cell Cycle. 2014. PMID: 24840740 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
