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. 2005;201(8-9):599-602.
doi: 10.1016/j.prp.2005.07.006.

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

Torsten Goldmann  1 , Daniel Drömann, Marouane Marzouki, Udo Schimmel, Karsten Debel, Detlev Branscheid, Tobias Zeiser, Jan Rupp, Johannes Gerdes, Peter Zabel, Ekkehard Vollmer
Affiliations

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

Torsten Goldmann et al. Pathol Res Pract. 2005.

Abstract

In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.

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