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Case Reports
. 2006 Oct 10;112(3):373-4.
doi: 10.1016/j.ijcard.2005.07.055. Epub 2005 Nov 2.

QT interval prolongation and torsade de pointes associated with indapamide

Konstantinos P Letsas, Ioannis P Alexanian, Loukas K Pappas, Stavros P Kounas, Michalis Efremidis, Antonios Sideris, Fotis Kardaras
Case Reports

QT interval prolongation and torsade de pointes associated with indapamide

Konstantinos P Letsas et al. Int J Cardiol. .

Abstract

Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report.

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