Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec;30(12):659-65.
doi: 10.1016/j.tibs.2005.10.006. Epub 2005 Nov 2.

Amino acid specificity in translation

Taraka Dale  1 , Olke C Uhlenbeck
Affiliations

Amino acid specificity in translation

Taraka Dale et al. Trends Biochem Sci. 2005 Dec.

Abstract

Recent structural and biochemical experiments indicate that bacterial elongation factor Tu and the ribosomal A-site show specificity for both the amino acid and the tRNA portions of their aminoacyl-tRNA (aa-tRNA) substrates. These data are inconsistent with the traditional view that tRNAs are generic adaptors in translation. We hypothesize that each tRNA sequence has co-evolved with its cognate amino acid, such that all aa-tRNAs are translated uniformly.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources