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Review
. 2005 Oct;8(1-2):83-9.
doi: 10.1007/BF03033821.

Human brain derived cell culture models of HIV-1 infection

P Seth  1 , E O Major
Affiliations
Review

Human brain derived cell culture models of HIV-1 infection

P Seth et al. Neurotox Res. 2005 Oct.

Abstract

During the clinical course of acquired immune deficiency syndrome, infection of the CNS by human immunodeficiency virus-1 (HIV-1) may ultimately result in the impairment of cognitive, behavioral and motor functions. Viral neuropathogenesis involves inflammatory molecules and neurotoxins produced from infected and immune-activated lymphocytes, microglial cells and astrocytes. Here, we discuss the current understanding of HIV-1 infection of the CNS and various cell culture systems from the developing human brain in order to study the neurobiology of HIV-1 infection, the mechanisms contributing to HIV-1 infection, and disease progression.

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