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. 2006 Jan 1;16(1):31-5.
doi: 10.1016/j.bmcl.2005.09.058. Epub 2005 Nov 2.

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Patricia Melnyk  1 , Virginie Leroux, Christian Sergheraert, Philippe Grellier
Affiliations

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Patricia Melnyk et al. Bioorg Med Chem Lett. .

Abstract

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.

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