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. 2005 Dec;12(6):1023-33.
doi: 10.1016/j.ymthe.2005.09.009. Epub 2005 Nov 2.

Identification of mouse AAV capsid-specific CD8+ T cell epitopes

Denise E Sabatino  1 , Federico Mingozzi, Daniel J Hui, Haifeng Chen, Peter Colosi, Hildegund C J Ertl, Katherine A High
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Free article

Identification of mouse AAV capsid-specific CD8+ T cell epitopes

Denise E Sabatino et al. Mol Ther. 2005 Dec.
Free article

Abstract

Adeno-associated virus has been developed for use as a gene transfer vector. To understand the impact of AAV capsid-specific CD8(+) T cells on AAV-mediated gene transfer, we identified CD8(+) T cell epitopes for AAV-2 and AAV-8 capsid in C57BL/6 (H-2(b) MHC haplotype) and BALB/c (H-2(d) MHC haplotype) mice. Mice of both the H-2(b) and the H-2(d) haplotypes recognized epitopes on AAV-2 and AAV-8 capsid. T cells from H-2(b) mice recognized an epitope that was conserved between AAV-2 and AAV-8 capsid. Cross-reactivity of AAV-specific CD8(+) T cells induced by different AAV serotypes may have important implications for gene transfer. Identification of these epitopes will facilitate studies of immune response to AAV capsid in mouse models.

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