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. 2005 Dec 1;41(11):1654-61.
doi: 10.1086/498029. Epub 2005 Oct 27.

Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants?

Louise Kuhn  1 , Prisca Kasonde, Moses Sinkala, Chipepo Kankasa, Katherine Semrau, Nancy Scott, Wei-Yann Tsai, Sten H Vermund, Grace M Aldrovandi, Donald M Thea
Affiliations

Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants?

Louise Kuhn et al. Clin Infect Dis. .

Abstract

Background: Rates of perinatal human immunodeficiency virus (HIV) transmission are higher among HIV-infected mothers with more advanced disease, but effects of maternal disease on HIV-uninfected offspring are unclear. We investigated the hypothesis that the severity of HIV disease and immune dysfunction among mothers is associated with increased morbidity and mortality among their uninfected infants.

Methods: In a birth cohort of 620 HIV-uninfected infants born to HIV-infected mothers in Lusaka, Zambia, we investigated associations between markers of more advanced maternal HIV disease and child mortality, hospital admissions, and infant weight through 4 months of age.

Results: Mortality in the cohort of uninfected infants was 4.6% (95% confidence interval [CI], 2.8-6.3) through 4 months of age. Infants of mothers with CD4+ T cell counts of <350 cells/microL were more likely to die (hazard ratio [HR], 2.87; 95% CI, 1.03-8.03) and were more likely to be hospitalized (HR, 2.28; 95% CI, 1.17-4.45), after adjusting for other factors, including maternal death and low birth weight. The most common cause of infant death and hospitalization was pneumonia and/or sepsis. A maternal viral load of >100,000 copies/mL was associated with significantly lower child weight through 4 months of age.

Conclusion: Children born to HIV-infected mothers with advanced disease who escaped perinatal or early breastfeeding-related HIV infection are nonetheless at high risk of mortality and morbidity during the first few months of life. HIV-related immunosuppression appears to have adverse consequences for the health of infants, in addition to risks of vertical transmission.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves of infant mortality (A) and time to first hospital admission (B) among 620 HIV-uninfected infants born to HIV-infected mothers, by maternal CD4+ T cell counts of <200 cells/μL, 200–349 cells/μL, and >349 cells/μL.
Figure 2
Figure 2
Weights of infants between 1 week and 4 months of age born to HIV-infected mothers, by maternal HIV load. Horizontal bars, median values; boxes, interquartile ranges; whiskers, 10th and 90th percentiles.
See this image and copyright information in PMC

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