The role of hybrid PET/CT in the evaluation of patients with cervical cancer
- PMID: 16269172
- DOI: 10.1016/j.ygyno.2005.07.013
The role of hybrid PET/CT in the evaluation of patients with cervical cancer
Erratum in
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Corrigendum to 'The role of hybrid PET/CT in the evaluation of patients with cervical cancer' [Gynecologic Oncology 100 (2005) 65-69].Gynecol Oncol. 2020 Nov;159(2):598. doi: 10.1016/j.ygyno.2020.07.001. Epub 2020 Sep 6. Gynecol Oncol. 2020. PMID: 32900502 No abstract available.
Abstract
Objective: To assess the role of hybrid PET/CT in the evaluation of patients with cervical cancer.
Methods: 75 patients divided into 3 groups. Group 1 consisted of 16 patients prior to radical surgery. Group 2 consisted of 31 patients prior to pelvic radiotherapy. Group 3 had 28 patients who underwent the examination secondary to suspected recurrent disease. Whole body PET and CT were performed respectively on the same device 1 h after injection of 10 mCi FDG. PET/CT results were correlated to histological, radiological and clinical follow-up data. Only women with >6 months follow-up were included.
Results: In 33 patients, pathohistological examinations for extra cervical lesions were obtained. Correlation with PET/CT examination revealed levels of sensitivity (60%), specificity (94%), positive (90%) and negative predictive values (74%). The examination indicated 21 patients with extrapelvic and/or metastatic disease. The follow-up data of this group revealed that 20 patients either died or were alive with active disease, and only one patient was in clinical remission. PET/CT yielded an improved diagnosis for both PET and CT in 43% of the cases by providing better localization and definition of abnormal FDG uptake.
Conclusions: Hybrid PET/CT was found to be of value for detection of cervical cancer metastases, decision-making and planning of irradiation therapy. Using this modality may reduce unnecessary surgical interventions, help modify radiation fields and change therapeutic approaches. Detection of advanced diseases on PET/CT correlates with poor prognosis. However, this examination is less accurate in detecting microscopic diseases and lesions smaller than 1.5 cm.
