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Comparative Study
. 2006 Feb;32(1):39-43.
doi: 10.1016/j.ejso.2005.09.011. Epub 2005 Nov 2.

Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

L B Been  1 , P H Elsinga, J de Vries, D C P Cobben, P L Jager, H J Hoekstra, A J H Suurmeijer
Affiliations
Comparative Study

Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

L B Been et al. Eur J Surg Oncol. 2006 Feb.

Abstract

Background: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.

Methods: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla.

Results: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.

Conclusions: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.

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