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Comment
. 2005 Nov 4;123(3):359-61.
doi: 10.1016/j.cell.2005.10.017.

Snaring the function of alpha-synuclein

Nancy M Bonini  1 , Benoit I Giasson
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Snaring the function of alpha-synuclein

Nancy M Bonini et al. Cell. .
Free article

Abstract

It is well established that the abundant neuronal protein alpha-synuclein has a causal role in Parkinson's disease, yet the normal functions of this protein remain unclear. In this issue of Cell, Chandra et al. (2005) reveal that alpha-synuclein acts as a molecular chaperone, assisting in the folding and refolding of synaptic proteins called SNAREs. These proteins are crucial for release of neurotransmitters at the neuronal synapse, vesicle recycling, and synaptic integrity.

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