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Comment
. 2005 Nov 4;123(3):361-3.
doi: 10.1016/j.cell.2005.10.013.

The proteasome: not just degrading anymore

Stephen P Baker  1 , Patrick A Grant
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Free article
Comment

The proteasome: not just degrading anymore

Stephen P Baker et al. Cell. .
Free article

Abstract

The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.

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