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doi: 10.1016/j.cell.2005.10.013.
The proteasome: not just degrading anymore
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- PMID: 16269325
- DOI: 10.1016/j.cell.2005.10.013
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The proteasome: not just degrading anymore
Cell.
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Abstract
The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.
Comment on
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The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators.Cell. 2005 Nov 4;123(3):423-36. doi: 10.1016/j.cell.2005.08.015. Cell. 2005. PMID: 16269334
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