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Comparative Study
. 2005 Nov;35(9):917-24.
doi: 10.1007/s11055-005-0146-6.

A model of anxious depression: persistence of behavioral pathology

D F Avgustinovich  1 , I L Kovalenko, N N Kudryavtseva
Affiliations
Comparative Study

A model of anxious depression: persistence of behavioral pathology

D F Avgustinovich et al. Neurosci Behav Physiol. 2005 Nov.

Abstract

Chronic psychoemotional stress induced by negative experience of social defeats in intermale confrontations over a period of 30 days was found to lead to the development of anxious-depressive symptomatology in male mice. Cessation of the psychopathogenic conditions and placing of depressed animals in comfortable conditions for 1-2 weeks with females did not lift the pathological state. Individuals continued to show marked anxiety, a behavioral deficit, decreased communicativeness, and a high level of depressivity, as revealed by a variety of behavioral tests. Persistence of the resulting psychoemotional disturbance in these animals is evidence for the development and persistence of the behavioral pathology requiring drug treatment.

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