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. 2005 Oct 19:1:10.
doi: 10.1186/1745-9974-1-10.

No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux

Alfonso Torrego  1 , Stefan Cimbollek, Mark Hew, Kian Fan Chung
Affiliations

No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux

Alfonso Torrego et al. Cough. .

Abstract

Background: Endogenous airway acidification evaluated as pH in exhaled breath condensate (EBC) has been described in patients with chronic cough. Proton pump inhibitors improve gastro-oesophageal reflux (GOR)-associated cough.

Methods: We examined pH levels in EBC and capsaicin cough response in 13 patients with chronic cough (mean age 41 years, SD 9) associated with GOR before and after omeprazole treatment (40 mg/day for 14 days) and its relationship with clinical response.

Results: Omeprazole abolished symptoms associated with GOR. Patients with chronic cough had an EBC pH of 8.28 (SD 0.13) prior to treatment but this did not change with omeprazole treatment. There was a significant improvement in the Leicester Cough Questionnaire symptom scores from 80.8 points (SD 13.2) to 95.1 (SD 17) (p = 0.02) and in a 6-point scale of cough scores, but there was no change in capsaicin cough response.

Conclusion: An improvement in GOR-associated cough was not associated with changes in EBC pH or capsaicin cough response. These parameters are not useful markers of therapeutic response.

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Figures

Figure 1
Figure 1
Cough scores measured by the Leicester Cough Questionnaire before and after 2 weeks of omeprazole treatment. * p = 0.02.
Figure 2
Figure 2
Cough reflex sensitivity to inhaled capsaicin measured as the concentration of capsaicin causing 5 or more coughs (C5) before and after omeprazole treatment.
Figure 3
Figure 3
pH values in exhaled breath condensate in patients before and after omeprazole treatment. There was no effect of omeprazole.
See this image and copyright information in PMC

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References

    1. Irwin RS, Curley FJ, French CL. Chronic cough: the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Amer Rev Respir Dis. 1990;141:640–7. - PubMed
    1. Fontana GA, Pistolesi M. Cough. 3: chronic cough and gastro-oesophageal reflux. Thorax. 2003;58:1092–5. doi: 10.1136/thorax.58.12.1092. - DOI - PMC - PubMed
    1. Poe RH, Kallay MC. Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment. Chest. 2003;123:679–84. doi: 10.1378/chest.123.3.679. - DOI - PubMed
    1. Ing AJ, Ngu MC. Cough and gastro-oesophageal reflux. Lancet. 1999;353:944–6. doi: 10.1016/S0140-6736(98)00354-7. - DOI - PubMed
    1. Ours TM, Kavuru MS, Schilz RJ, Richter JE. A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol. 1999;94:3131–8. doi: 10.1111/j.1572-0241.1999.01504.x. - DOI - PubMed

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