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. 2006 Mar 6;24(10):1586-92.
doi: 10.1016/j.vaccine.2005.10.008. Epub 2005 Oct 18.

Long-term clinical trial safety experience with the inactivated split influenza vaccine, Vaxigrip

Affiliations

Long-term clinical trial safety experience with the inactivated split influenza vaccine, Vaxigrip

Valentine Delore et al. Vaccine. .

Abstract

Safety data on the inactivated split influenza vaccine, Vaxigrip, were compiled and analysed from 28 clinical trials (total: 4599 subjects aged 6 months to 99 years) to provide a robust estimate of the reactogenicity profile. The most frequent solicited reactions were non-severe injection site pain and erythema in children, adults, and elderly. Mild or moderate fever was the most frequent reaction in 6-36 months olds; few systemic reactions were reported in older groups. Reactogenicity was comparable in healthy and high-risk children. The long-term experience with the world's most widely used influenza vaccine, Vaxigrip, confirms its excellent tolerability, and supports its continued use in clinical practice worldwide.

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