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Case Reports
. 1992 Jul;9(4):247-9.
doi: 10.1055/s-2007-994781.

Zidovudine pharmacokinetics during pregnancy

R S Sperling  1 , J Roboz, R Dische, D Silides, I Holzman, E Jew
Affiliations
Case Reports

Zidovudine pharmacokinetics during pregnancy

R S Sperling et al. Am J Perinatol. 1992 Jul.

Abstract

As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.

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