Case Reports
doi: 10.1055/s-2007-994781.
Zidovudine pharmacokinetics during pregnancy
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- PMID: 1627212
- DOI: 10.1055/s-2007-994781
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Case Reports
Zidovudine pharmacokinetics during pregnancy
Am J Perinatol.
1992 Jul.
Abstract
As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.
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