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. 2006 Feb;16(3):628-32.
doi: 10.1016/j.bmcl.2005.10.052. Epub 2005 Nov 3.

Pyrrolopyridazine MEK inhibitors

Zhong Chen  1 , Soong-Hoon Kim, Stephanie A Barbosa, Tram Huynh, David R Tortolani, Kenneth J Leavitt, Donna D Wei, Veeraswamy Manne, Carolyn S Ricca, Johnni Gullo-Brown, Michael A Poss, Wayne Vaccaro, Mark E Salvati
Affiliations

Pyrrolopyridazine MEK inhibitors

Zhong Chen et al. Bioorg Med Chem Lett. 2006 Feb.

Abstract

The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.

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