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Comparative Study
. 2005 Nov 8;65(9):1483-6.
doi: 10.1212/01.wnl.0000183067.94400.80.

Gray matter decrease in patients with chronic tension type headache

T Schmidt-Wilcke  1 , E Leinisch, A Straube, N Kämpfe, B Draganski, H C Diener, U Bogdahn, A May
Affiliations
Comparative Study

Gray matter decrease in patients with chronic tension type headache

T Schmidt-Wilcke et al. Neurology. .

Abstract

Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.

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