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Comment
. 2005 Nov 15;102(46):16535-6.
doi: 10.1073/pnas.0508350102. Epub 2005 Nov 7.

Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis

Chenjian Li  1 , M Flint Beal
Affiliations
Comment

Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis

Chenjian Li et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
LRRK2 domain structures and mutations. LRRK2 has 2,527 amino acids and contains a LRR domain (for protein/protein interaction), Ras-in-complex and C-terminal of ROC domain (GTPase), Ser/Thr kinase domain, and WD40 domain (for protein/protein interactions). Numbers above the protein line indicate the boundaries of each domain. Numbers below the protein line indicate mutations. G2019S (mutation 11) and R1441C (mutation 4) are the two mutations that West et al. (6) used in their experiments.
Fig. 2.
Fig. 2.
A model of mitochondria and PD pathogenesis. Cellular damage by mutations in DJ-1, PINK1, LRRK2, and PARKIN may converge on mitochondria. Identifying the specific aspects of mitochondrial dysfunction is the next challenge.
See this image and copyright information in PMC

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