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. 2006;9(1):83-91.
doi: 10.1038/sj.pcan.4500837.

Brn-3a neuronal transcription factor functional expression in human prostate cancer

J K J Diss  1 , D J Faulkes, M M Walker, A Patel, C S Foster, V Budhram-Mahadeo, M B A Djamgoz, D S Latchman
Affiliations

Brn-3a neuronal transcription factor functional expression in human prostate cancer

J K J Diss et al. Prostate Cancer Prostatic Dis. 2006.

Abstract

Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.

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