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. 2005 Nov;2(11):829-31.
doi: 10.1038/nmeth797.

G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs

Hidetoshi Tahara  1 , Mayuko Kusunoki, Yusuke Yamanaka, Shusaku Matsumura, Toshinori Ide
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G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs

Hidetoshi Tahara et al. Nat Methods. 2005 Nov.

Abstract

Accurate measurement of telomeric 3'-overhang (G-tail) lengths is essential for investigation of the biological effects of telomere dysfunction. G-tail telomere hybridization protection assay (Gt-telomere HPA) has the advantages of being simple to perform, accurate and highly sensitive for G tails as short as 20 nucleotides. Furthermore, Gt-telomere HPA is specific and quantitative for human G tails, and can be used to assay cell lysates as well as genomic DNA.

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