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. 2005;7(6):R890-6.
doi: 10.1186/bcr1319. Epub 2005 Sep 14.

CYP17 gene polymorphism in relation to breast cancer risk: a case-control study

Kristjana Einarsdóttir  1 , Tove Rylander-Rudqvist, Keith Humphreys, Susanne Ahlberg, Gudrun Jonasdottir, Elisabete Weiderpass, Kee Seng Chia, Magnus Ingelman-Sundberg, Ingemar Persson, Jianjun Liu, Per Hall, Sara Wedrén
Affiliations

CYP17 gene polymorphism in relation to breast cancer risk: a case-control study

Kristjana Einarsdóttir et al. Breast Cancer Res. 2005.

Abstract

Introduction: The c.1-34T>C 5' promoter region polymorphism in cytochrome P450c17 (CYP17), a key enzyme in the biosynthesis of estrogen, has been associated with breast cancer risk, but most previous studies have been relatively small.

Methods: We genotyped 1,544 incident cases of primary breast cancer and 1,502 population controls, all postmenopausal Swedish women, for the CYP17 c.1-34T>C polymorphism and calculated odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.

Results: No overall association was found between CYP17 c.1-34T>C and breast cancer risk, OR 1.0 (95% CI 0.8-1.3) for the A2/A2 (CC) carriers compared to the A1/A1 (TT) carriers, regardless of histopathology. We detected an interaction between CYP17 c.1-34T>C and age at menarche (P = 0.026) but regarded that as a chance finding as no dose-response pattern was evident. Other breast cancer risk factors, including menopausal hormone use and diabetes mellitus, did not modify the overall results.

Conclusion: It is unlikely that CYP17 c.1-34T>C has a role in breast cancer etiology, overall or in combination with established non-genetic breast cancer risk factors.

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