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. 2005 Nov;73(5):839-41.

Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America

Franklyn Samudio  1 , Ana M Santamaría, Nicanor Obaldía 3rd, Juan M Pascale, Vicente Bayard, Jose E Calzada
Affiliations
  • PMID: 16282290

Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America

Franklyn Samudio et al. Am J Trop Med Hyg. 2005 Nov.

Abstract

A molecular epidemiology study was conducted to determine the distribution of antimalarial drug resistance alleles among field isolates of Plasmodium falciparum. Samples were obtained during an epidemic affecting Kuna Amerindians in Panama. A high prevalence of mutations associated with chloroquine, pyrimethamine, and sulfadoxine was observed. Genotype analysis of msp2 revealed a low genetic diversity of P. falciparum parasites circulating in the studied area. The public health implications of these findings for the Central American region are discussed.

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