Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec;48(12):2667-74.
doi: 10.1007/s00125-005-0005-6. Epub 2005 Nov 8.

Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta

A Otsuka  1 , K Azuma, T Iesaki, F Sato, T Hirose, T Shimizu, Y Tanaka, H Daida, R Kawamori, H Watada
Affiliations

Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta

A Otsuka et al. Diabetologia. 2005 Dec.

Abstract

Aims/hypothesis: Several epidemiological data suggest that patients with postprandial hyperglycaemia are at high risk of cardiovascular disease. The aim of this study was to elucidate the effect of a glucose 'spike' on monocyte adhesion to rat aortic endothelial cells.

Materials and methods: Monocyte adhesion to endothelial cells in vivo was quantitated using an en face method for observation of endothelial surface after immunohistochemical staining for CD68 in the thoracic aortas of Sprague-Dawley rats after several kinds of blood glucose rises.

Results: The number of monocytes adhering to endothelial cells increased at 30 min after injection of glucose in 8-week-old Sprague-Dawley rats. The increased adhesion returned to the basal level at 120 min after glucose injection, concomitantly with the return of blood glucose levels to normal. The infusion of octreotide to inhibit endogenous insulin secretion did not prevent the glucose-induced increase in monocyte adhesion to endothelial cells. On the other hand, the number of monocytes adhering to endothelial cells did not increase in rats with streptozotocin-induced diabetes and sustained hyperglycaemia.

Conclusions/interpretation: Our data demonstrate that a temporary rise in blood glucose levels can in itself promote a reversible increase in monocyte adhesion to arterial endothelial cells.

PubMed Disclaimer

References

    1. Lancet. 1980 Jun 28;1(8183):1373-6 - PubMed
    1. J Am Coll Cardiol. 1999 Jul;34(1):146-54 - PubMed
    1. Diabetes. 1994 Sep;43(9):1103-7 - PubMed
    1. Diabetes. 2003 Nov;52(11):2795-804 - PubMed
    1. Am J Cardiol. 1999 Nov 15;84(10):1272-4, A9 - PubMed

Publication types

MeSH terms