Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Dec;58(6):840-6.
doi: 10.1002/ana.20703.

Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"

Chris H Polman  1 , Stephen C Reingold, Gilles Edan, Massimo Filippi, Hans-Peter Hartung, Ludwig Kappos, Fred D Lublin, Luanne M Metz, Henry F McFarland, Paul W O'Connor, Magnhild Sandberg-Wollheim, Alan J Thompson, Brian G Weinshenker, Jerry S Wolinsky
Affiliations
Review

Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"

Chris H Polman et al. Ann Neurol. 2005 Dec.

Abstract

New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity.

PubMed Disclaimer

Comment in

LinkOut - more resources