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Comment
. 2005 Nov 11;310(5750):980-2.
doi: 10.1126/science.1120280.

Chemistry. Following the flow of energy in biomolecules

Paul M Champion  1
Affiliations
Comment

Chemistry. Following the flow of energy in biomolecules

Paul M Champion. Science. .
No abstract available

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Figures

Figure
Figure. Good vibrations
(Top) A top-down view of the intersection of the initial photoexcited-state electronic surface (thin tan contour lines) of the heme in ligated myoglobin (labeled MbL*) and the photoproduct ground-state electronic surface (labeled Mb). After photoexcitation of the π-electrons of the heme chromophore (yellow region), the iron d-electrons rapidly reconfigure within their localized orbitals and go from a spin of S = 0 in MbL* to S = 2 in Mb. This exerts strong local forces on the nuclei surrounding the iron atom that move the system along the coordinate(s) q. The simplified picture depicts the photodissociation of the diatomic ligand (blue circles labeled L) along the iron-ligand coordinate r, as well as the coupling of the reaction to other chromophore and/or protein modes labeled q. The ensuing coherent vibrations of the reaction-coupled q-modes are specific to the ground state and appear within 100 fs of the photochemical pump (7, 10). (Bottom) The thermally activated reverse reaction as the ligand binds to the heme along the ground-state electronic surface. The diatomic ligand is “trapped” by electronic coupling to nuclear coordinate(s) q when the period (τq) for the return to the binding seam is longer than the time it takes to dissipate vibrational energy.
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Comment on

References

    1. Champion PM, Lange R. J Chem Phys. 1980;73:5947.
    1. Breton J, Martin JL, Mingus A, Antonetti A, Orszag A. Proc Natl Acad Sci USA. 1986;83:5121. - PMC - PubMed
    1. Schoenlein RW, Peteanu LA, Mathies RA, Shank CV. Science. 1991;254:412. - PubMed
    1. Kukura P, McCamant DW, Yoon S, Wandschneider DB, Mathies RA. Science. 2005;310:1006. - PubMed
    1. Zewail A. Pure Appl Chem. 2000;72:2219.