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Clinical Trial
. 2005 Dec 2;19(18):2167-9.
doi: 10.1097/01.aids.0000194800.43799.94.

Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Susan H Eshleman  1 , Donald R Hoover, Shu Chen, Sarah E Hudelson, Laura A Guay, Anthony Mwatha, Susan A Fiscus, Francis Mmiro, Philippa Musoke, J Brooks Jackson, Newton Kumwenda, Taha Taha
Affiliations
Clinical Trial

Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Susan H Eshleman et al. AIDS. .

Abstract

The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).

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