Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2005 Nov 18;123(4):543-5.
doi: 10.1016/j.cell.2005.11.006.

RNAi: RISC gets loaded

Jonathan B Preall  1 , Erik J Sontheimer
Affiliations
Free article
Comment

RNAi: RISC gets loaded

Jonathan B Preall et al. Cell. .
Free article

Abstract

When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two approximately 21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities.

PubMed Disclaimer

Comment on

MeSH terms

LinkOut - more resources