Comment
doi: 10.1016/j.cell.2005.11.002.
The enigmatic role of Sir2 in aging
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- PMID: 16286003
- DOI: 10.1016/j.cell.2005.11.002
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Comment
The enigmatic role of Sir2 in aging
Cell.
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Abstract
In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.
Comment on
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Sir2 blocks extreme life-span extension.Cell. 2005 Nov 18;123(4):655-67. doi: 10.1016/j.cell.2005.08.042. Cell. 2005. PMID: 16286010
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