Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2005 Nov 18;123(4):548-50.
doi: 10.1016/j.cell.2005.11.002.

The enigmatic role of Sir2 in aging

Brian K Kennedy  1 , Erica D Smith, Matt Kaeberlein
Affiliations
Free article
Comment

The enigmatic role of Sir2 in aging

Brian K Kennedy et al. Cell. .
Free article

Abstract

In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

PubMed Disclaimer

Comment on

  • Sir2 blocks extreme life-span extension.
    Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. Fabrizio P, et al. Cell. 2005 Nov 18;123(4):655-67. doi: 10.1016/j.cell.2005.08.042. Cell. 2005. PMID: 16286010

MeSH terms

LinkOut - more resources