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. 2005 Nov;23(5):461-2.
doi: 10.1016/j.immuni.2005.10.004.

An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

Charles A Dinarello  1
Affiliations
Free article

An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

Charles A Dinarello. Immunity. 2005 Nov.
Free article

Abstract

Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.

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