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Comment
. 2005 Nov;8(5):349-50.
doi: 10.1016/j.ccr.2005.10.018.

The dual adverse effects of TGF-beta secretion on tumor progression

Joseph A Trapani  1
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Free article
Comment

The dual adverse effects of TGF-beta secretion on tumor progression

Joseph A Trapani. Cancer Cell. 2005 Nov.
Free article

Abstract

When a cancer escapes the growth-inhibitory effects of TGF-beta secreted by cancer cells themselves or by cells in the local stroma, a further adverse outcome for the host is the associated TGF-beta-induced suppression of anticancer T cell immunity. In addition to the previously described dampening of T cell activation and proliferation, TGF-beta markedly and directly suppresses the transcription of genes encoding multiple key proteins of the "cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act through the granule exocytosis pathway. The findings described below suggest that TGF-beta and its signaling pathways will be major targets for novel cancer therapeutics.

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