A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathways
- PMID: 16286242
- DOI: 10.1016/j.ccr.2005.10.016
A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathways
Abstract
Skeletal muscle atrophy is a common comorbidity of cancer. The cellular signaling mechanisms that regulate muscle size constitute a balance of the protein breakdown pathways upregulated during atrophy, and the protein synthesis pathways that are activated during skeletal muscle hypertrophy. In this issue of Cancer Cell, Acharyya et al. demonstrate a new and surprising regulatory axis that is centered around dystrophin, the protein that is mutated in settings of muscular dystrophy. These data reposition dystrophin as a signaling protein and connect an important cellular complex required for the structural integrity of muscle to the pathways that modulate muscle size.
Comment on
-
Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.Cancer Cell. 2005 Nov;8(5):421-32. doi: 10.1016/j.ccr.2005.10.004. Cancer Cell. 2005. PMID: 16286249
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources