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. 2005 Nov 23;127(46):15998-9.
doi: 10.1021/ja054114s.

Ruthenium-catalyzed cycloaddition of alkynes and organic azides

Li Zhang  1 , Xinguo Chen, Peng Xue, Herman H Y Sun, Ian D Williams, K Barry Sharpless, Valery V Fokin, Guochen Jia
Affiliations

Ruthenium-catalyzed cycloaddition of alkynes and organic azides

Li Zhang et al. J Am Chem Soc. .

Abstract

Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

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