Review
doi: 10.1152/physiol.00032.2005.
Acid acclimation by Helicobacter pylori
Affiliations
- PMID: 16287992
- DOI: 10.1152/physiol.00032.2005
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Review
Acid acclimation by Helicobacter pylori
Physiology (Bethesda).
2005 Dec.
Free article
Abstract
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
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