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Review
. 2005 Dec:20:429-38.
doi: 10.1152/physiol.00032.2005.

Acid acclimation by Helicobacter pylori

George Sachs  1 , David L Weeks, Yi Wen, Elizabeth A Marcus, David R Scott, Klaus Melchers
Affiliations
Free article
Review

Acid acclimation by Helicobacter pylori

George Sachs et al. Physiology (Bethesda). 2005 Dec.
Free article

Abstract

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.

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