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Comparative Study
. 2005 Dec;11(12):1290-2.
doi: 10.1038/nm1333. Epub 2005 Nov 20.

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

Xiaojiang Gao  1 , Arman Bashirova, Astrid K N Iversen, John Phair, James J Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Marcus Altfeld, Stephen J O'Brien, Mary Carrington
Affiliations
Comparative Study

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

Xiaojiang Gao et al. Nat Med. 2005 Dec.

Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

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