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Comment
. 2005 Nov;2(11):e399.
doi: 10.1371/journal.pmed.0020399. Epub 2005 Nov 29.

Restoring retinal function in a mouse model of hereditary blindness

Tony Moore  1
Affiliations
Comment

Restoring retinal function in a mouse model of hereditary blindness

Tony Moore. PLoS Med. 2005 Nov.

Abstract

Moore discusses a new study showing rescue of photoreceptor function using gene and drug therapies in a mouse model of Leber congenital amaurosis.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The author declares that no competing interests exist.

Figures

Figure 1
Figure 1. The Visual Cycle
(Illustration: Giovanni Maki, adapted from [4])
See this image and copyright information in PMC

Comment on

References

    1. Rahi JS, Cable N. Severe visual impairment and blindness in children in the UK. Lancet. 2003;362:1359–1365. - PubMed
    1. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, et al. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med. 2005;2:e333. doi: 10.1371/journal.pmed.0020333. - DOI - PMC - PubMed
    1. Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet. 2001;28:92–95. - PubMed
    1. Sparrow JR. Therapy for macular degeneration: Insights from acne. Proc Natl Acad Sci U S A. 2003;100:4353–4354. - PMC - PubMed