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Case Reports
. 2006 Feb;100(2):184-6.
doi: 10.1016/j.trstmh.2005.01.008. Epub 2005 Nov 10.

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N Newton  1 , Steven Ward, Brian J Angus, Wirongrong Chierakul, Arjen Dondorp, Ronnatrai Ruangveerayuth, Kamolrat Silamut, Pramote Teerapong, Yupin Suputtamongkol, Sornchai Looareesuwan, Nicholas J White
Affiliations
Case Reports

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N Newton et al. Trans R Soc Trop Med Hyg. 2006 Feb.

Abstract

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.

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