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. 1992 Aug;174(15):5141-4.
doi: 10.1128/jb.174.15.5141-5144.1992.

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens

O Hara  1 , C R Hutchinson
Affiliations

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens

O Hara et al. J Bacteriol. 1992 Aug.

Abstract

The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.

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