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. 2005 Nov 18;310(5751):1180-3.
doi: 10.1126/science.1119409.

Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis

Volker Lipka  1 , Jan Dittgen, Pawel Bednarek, Riyaz Bhat, Marcel Wiermer, Monica Stein, Jörn Landtag, Wolfgang Brandt, Sabine Rosahl, Dierk Scheel, Francisco Llorente, Antonio Molina, Jane Parker, Shauna Somerville, Paul Schulze-Lefert
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Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis

Volker Lipka et al. Science. .

Abstract

Nonhost resistance describes the immunity of an entire plant species against nonadapted pathogen species. We report that Arabidopsis PEN2 restricts pathogen entry of two ascomycete powdery mildew fungi that in nature colonize grass and pea species. The PEN2 glycosyl hydrolase localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. Postinvasion fungal growth is blocked by a separate resistance layer requiring the EDS1-PAD4-SAG101 signaling complex, which is known to function in basal and resistance (R) gene-triggered immunity. Concurrent impairment of pre- and postinvasion resistance renders Arabidopsis a host for both nonadapted fungi.

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