Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Nov 19;331(7526):1183-5.
doi: 10.1136/bmj.38663.459039.7C.

Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study

Ilkka Kalliala  1 , Ahti Anttila, Eero Pukkala, Pekka Nieminen
Affiliations

Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study

Ilkka Kalliala et al. BMJ. .

Abstract

Objective: To study the long term risk of cervical and other cancers after treatment for cervical intraepithelial neoplasia.

Design: Retrospective cohort study.

Setting: University Hospital, Helsinki, Finland.

Participants: 7564 women treated for cervical intraepithelial neoplasia during 1974 and 2001 and followed up through the Finnish cancer registry until 2003.

Main outcome measures: Standardised incidence ratio for cervical cancer and other cancers.

Results: During follow-up 22 cases of invasive cervical cancer occurred in women treated for cervical intraepithelial neoplasia (standardised incidence ratio 2.8, 95% confidence interval 1.7 to 4.2). The highest risk was during the second decade (10 cases observed: 3.1, 1.5 to 5.7). The standardised incidence ratio for cervical intraepithelial cancer type 1 was 3.1 (1.4 to 6.2) and for type 2 was 3.7 (0.9 to 10.7).

Conclusions: The risk of cervical cancer in the first 20 years after treatment for cervical intraepithelial neoplasia is higher than in the average population. The risk of smoking related cancers is also increased.

PubMed Disclaimer

References

    1. International Agency for Research on Cancer. Cervical cancer screening. IARC handbooks of cancer prevention, vol 10. Lyon: IARC/WHO, 2005: 302.
    1. Anttila A, Läärä E. In: Sankila R, Démaret E, Hakama M, Lynge E, Schouten LJ, Parkin DM, for the European Network of Cancer Registries. Evaluating and monitoring of screening programmes. Brussels/Luxembourg: European Commission, Europe Against Cancer Programme, 2000.
    1. Martin-Hirsch PL, Paraskevaidis E, Kitchener H. Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev 1999;(3): CD001318. DOI: 10.1002/14651858.CD001318. - DOI - PubMed
    1. Soutter WP, de Barros Lopes A, Fletcher A, Monaghan JM, Duncan ID, Paraskevaidis E, et al. Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet 1997;349: 978-80. - PubMed
    1. Teppo L, Pukkala E, Lehtonen M. Data quality and quality control of a population-based cancer registry. Acta Oncol 1994;33: 365-9. - PubMed

Publication types

MeSH terms