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Review
. 2005 Dec;73(12):7791-6.
doi: 10.1128/IAI.73.12.7791-7796.2005.

Membrane cholesterol: a crucial molecule affecting interactions of microbial pathogens with mammalian cells

P Goluszko  1 , B Nowicki
Affiliations
Review

Membrane cholesterol: a crucial molecule affecting interactions of microbial pathogens with mammalian cells

P Goluszko et al. Infect Immun. 2005 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Conceptual model of cholesterol effects on the traffic of microbial pathogens into or out of the eukaryotic cell. (A) The bacterial pathogen interacts directly with membrane cholesterol, which serves as a “docking site” and stabilizes microbial interaction with membranes. (B) The bacterial pathogen interacts directly with a GPI-anchored protein receptor embedded in lipid rafts. Cholesterol is required to maintain lipid raft integrity. (C) The internalized microorganism resides within a phagosome with a cholesterol-enriched membrane. Cholesterol is required to prevent phagolysosomal fusion. (D) Viral particles (HIV-1) are targeted to lipid rafts. Cholesterol is required to maintain virion integrity and the release of infectious virions.
See this image and copyright information in PMC

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