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. 2005 Nov-Dec;20(6):468-72.
doi: 10.1590/s0102-86502005000600013. Epub 2005 Nov 8.

[Effect of allopurinol on rat testicles morphology, submitted to ischaemia for spermatic cord torsion followed by reperfusion]

[Article in Portuguese]
Andréia C M Brochado Antoniolli Silva  1 , Valdemar Ortiz, Roberto Antoniolli da Silva, João Ricardo Tognini
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Free article

[Effect of allopurinol on rat testicles morphology, submitted to ischaemia for spermatic cord torsion followed by reperfusion]

[Article in Portuguese]
Andréia C M Brochado Antoniolli Silva et al. Acta Cir Bras. 2005 Nov-Dec.
Free article

Abstract

Purpose: In this investigation has been studied the effect of the allopurinol on the reperfusion injury phenomenon in testicles of rats.

Methods: Eighty adults Wistar rats were divided in 4 groups: sham without allopurinol, sham with allopurinol, right testicular torsion for one hour without allopurinol and right testicular torsion for one hour with allopurinol. Bilateral orchiectomy was performed 60 days of the experiment and the testis were processed for optical microscopy, and examined to asses the seminiferous ducts and the spermatogenic cells.

Results: There was significant atrophy and histological damage of the right testis.

Conclusion: Allopurinol did not protected the testis against the effects of the reperfusion injury.

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