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. 2006 Jan;28(1):64-73.
doi: 10.1002/hed.20299.

Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation

Jeri A Logemann  1 , Alfred W Rademaker, Barbara Roa Pauloski, Cathy L Lazarus, Bharat B Mittal, Bruce Brockstein, Ellen MacCracken, Daniel J Haraf, Everett E Vokes, Lisa A Newman, Dachao Liu
Affiliations

Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation

Jeri A Logemann et al. Head Neck. 2006 Jan.

Abstract

Background: The relationship between type of chemoradiation treatment, site of disease, and swallowing function has not been sufficiently examined in patients with head and neck cancer treated primarily with chemoradiation.

Methods: Fifty-three patients with advanced-stage head and neck cancer were evaluated before and 3 months after chemoradiation treatment to define their swallowing disorders and characterize their swallowing physiology by site of lesion and chemoradiation protocol. One hundred forty normal subjects were also studied.

Results: The most common disorders at baseline and 3 months after treatment were reduced tongue base retraction, reduced tongue strength, and slowed or delayed laryngeal vestibule closure. Frequency of functional swallow did not differ significantly across disease sites after treatment, although frequency of disorders was different at various sites of lesion. The effects of the chemotherapy protocols were small.

Conclusions: The site of the lesion affects the frequency of occurrence of specific swallow disorders, whereas chemoradiation protocols have minimal effect on oropharyngeal swallow function.

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References

    1. David J, Paty E, Bachaud J, Vignaud J. Tongue necrosis after radiotherapy. Arterial disease after radiotherapy. Rev Stomatol Chir Maxillofac. 1989;90:334–336. - PubMed
    1. Eisbruch A, Lyden T, Bradford CR, et al. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53:23–28. - PubMed
    1. Eisele DW, Koch DG, Tarazi AE, Jones B. Aspiration from delayed radiation fibrosis of the neck. Dysphagia. 1991;6:120–122. - PubMed
    1. Ekberg O, Nylander G. Pharyngeal dysfunction after treatment for pharyngeal cancer with surgery and radiotherapy. Gastrointestinal Radiology. 1983;8:97–104. - PubMed
    1. Puthawala A, Nisar Syed A, Eads D, Gillin L, Gates T. Limited external beam and interstitial 192-irridium irradiation in the treatment of carcinoma of the base of the tongue: a ten year experience. Int J Radiat Oncol Biol Phys. 1988;14:839–848. - PubMed