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Comparative Study
. 1992 Jul;9(4):678-87.
doi: 10.1093/oxfordjournals.molbev.a040752.

Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases

K Tamura  1
Affiliations
Comparative Study

Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases

K Tamura. Mol Biol Evol. 1992 Jul.

Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

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